abstract：:Liver fibrosis often appears in chronic liver disease, with extracellular matrix (ECM) deposition as the main feature. Due to the presence of the liver-gut axis, the destruction of intestinal homeostasis is often accompanied by the development of liver fibrosis. The inconsistent ecological environment of different int...

journal_title：PeerJ

authors： Wan S,Huang C,Wang A,Zhu X

更新日期：2020-04-24 00:00:00

abstract：Background:Evidences indicated that non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) might originate from the same cell type, which however ended up to be two different subtypes of lung carcinoma, requiring different therapeutic regimens. We aimed to identify the differences between these two subtyp...

journal_title：PeerJ

authors： Wu J,Hao Z,Ma C,Li P,Dang L,Sun S

更新日期：2020-04-23 00:00:00

abstract：Background:Banteng (Bos javanicus d'Alton 1823) are an endangered species, highly sensitive to habitat structure and quality. In many areas, banteng were extinct and needed to be reintroduced to restore their population. Thus, understanding the responses of body condition of reintroduced banteng to their habitat was im...

journal_title：PeerJ

authors： Kongsurakan P,Chaiyarat R,Nakbun S,Thongthip N,Anuracpreeda P

更新日期：2020-04-23 00:00:00

abstract：:Organic fertilizer application could have an impact on the nitrogen cycle mediated by microorganisms in arable soils. However, the dynamics of soil ammonia oxidizers and denitrifiers in response to compost addition are less understood. In this study, we examined the effect of four compost application rates (0, 11.25, ...

journal_title：PeerJ

authors： Yang Z,Guan Y,Bello A,Wu Y,Ding J,Wang L,Ren Y,Chen G,Yang W

更新日期：2020-04-21 00:00:00

abstract：Background:Conserved nucleic acid sequences play an essential role in transcriptional regulation. The motifs/templates derived from nucleic acid sequence datasets are usually used as biomarkers to predict biochemical properties such as protein binding sites or to identify specific non-coding RNAs. In many cases, templa...

journal_title：PeerJ

authors： Peng H

更新日期：2020-04-20 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) colonization, sampled at 32-50 days post-inoculation (dpi), was significantly reduced in suppressor of prosystemin-mediated responses2 (spr2) mutant tomato plants impaired in the ω-3 FATTY ACID DESATURASE7 (FAD7) gene that limits the generation of linolenic acid and, consequently, th...

journal_title：PeerJ

authors： Casarrubias-Castillo K,Montero-Vargas JM,Dabdoub-González N,Winkler R,Martinez-Gallardo NA,Zañudo-Hernández J,Avilés-Arnaut H,Délano-Frier JP

更新日期：2020-04-16 00:00:00

abstract：Background:The meat quality of yellow feathered broilers is better than the quality of its production. Growth traits are important in the broiler industry. The exploration of regulation mechanisms for the skeletal muscle would help to increase the growth performance of chickens. At present, some progress has been made ...

journal_title：PeerJ

authors： Wu P,Zhang X,Zhang G,Chen F,He M,Zhang T,Wang J,Xie K,Dai G

更新日期：2020-04-15 00:00:00

abstract：:Weaning is an important event for all mammals, including young forest musk deer. However, weaning stress may cause intestinal microbiota-related disorders. Therefore, high-throughput 16S rRNA gene sequencing was applied to study the dynamic changes in intestinal microbiota during pre-weaning (10 days before weaning) a...

journal_title：PeerJ

authors： Li Y,Shi M,Zhang T,Hu X,Zhang B,Xu S,Ding J,Hu D,Liu S

更新日期：2020-04-13 00:00:00

abstract：:A prolonged preservation duration of blood specimens at 4 °C may occur due to the distance from collection points to storage facilities in many biobanks, especially for multicenter studies. This could lead to RNA degradation, affecting downstream analyses. However, effects of preservation durations at 4 °C on RNA qual...

journal_title：PeerJ

authors： Song J,Zhou J

更新日期：2020-04-10 00:00:00

abstract：:Twist1, a basic helix-loop-helix transcription factor that regulates a number of genes involved in epithelial-to-mesenchymal transition (EMT), is upregulated in prostate cancer. Androgen regulation of Twist1 has been reported in a previous study. However, the mechanism of androgen regulation of the Twist1 gene is not ...

journal_title：PeerJ

authors： Khatiwada P,Kannan A,Malla M,Dreier M,Shemshedini L

更新日期：2020-04-09 00:00:00

abstract：:Because cancer evolution underlies the therapeutic difficulties of cancer, it is clinically important to understand the evolutionary dynamics of cancer. Thus far, a number of evolutionary processes have been proposed to be working in cancer evolution. However, there exists no simulation model that can describe the dif...

journal_title：PeerJ

authors： Niida A,Hasegawa T,Innan H,Shibata T,Mimori K,Miyano S

更新日期：2020-04-08 00:00:00

abstract：:Allium tenuissimum L. is a widely distributed perennial herbaceous species in temperate and desert steppes. Relative to other wild Allium species, it produces unique sweet flavors, more biomass in arid and cold environments, and has generated greater interest for crop production. Successful crop establishment, however...

journal_title：PeerJ

authors： Xiao H,Yang H,Monaco T,Song Q,Rong Y

更新日期：2020-04-07 00:00:00

abstract：:The culture of pelagic marine invertebrates, especially the ctenophore Mnemiopsis leidyi, has been demonstrated in past studies dating back to the 1960s; however, the mass culture of delicate pelagic invertebrates has remained elusive. By using a pair of acrylic tubes and enabling water diffusion between them, we have...

journal_title：PeerJ

authors： Patry WL,Bubel M,Hansen C,Knowles T

更新日期：2020-04-07 00:00:00

abstract：Background:It was well known that age has an impact on word processing (word frequency or predictability) in terms of fixating time during reading. However, little is known about whether or not age modulates these impacts on saccade behaviors in Chinese reading (i.e., length of incoming/outgoing saccades for a target w...

journal_title：PeerJ

authors： Liu Z,Tong W,Su Y

更新日期：2020-04-01 00:00:00

abstract：:Esophageal cancer is a common malignant tumor in the world, and the aim of this study was to screen key genes related to the development of esophageal cancer using a variety of bioinformatics analysis tools and analyze their biological functions. The data of esophageal squamous cell carcinoma from the Gene Expression ...

journal_title：PeerJ

authors： Guan X,Yao Y,Bao G,Wang Y,Zhang A,Zhong X

更新日期：2020-03-31 00:00:00

abstract：Background:During their long evolution, Synechocystis sp. PCC6803 developed a remarkable capacity to acclimate to diverse environmental conditions. In this study, Raman spectroscopy and Raman chemometrics tools (RametrixTM) were employed to investigate the phenotypic changes in response to external stressors and correl...

journal_title：PeerJ

authors： Tanniche I,Collakova E,Denbow C,Senger RS

更新日期：2020-03-30 00:00:00

abstract：Background:During a preliminary study, effects of 0, 20, 40, and 60 mM NaCl salinity were assessed on germination rate in relation to electrolyte leakage (EL) in sweet pepper. Results explored significant rises in ethylene evolution from seeds having more EL. It was, therefore, hypothesized that excessive ethylene bios...

journal_title：PeerJ

authors： Ahmed W,Imran M,Yaseen M,Haq TU,Jamshaid MU,Rukh S,Ikram RM,Ali M,Ali A,Maqbool M,Arif M,Khan MA

更新日期：2020-03-27 00:00:00

abstract：Background:The body of literature regarding the associations between physical activity and psychological problems lacks consensus. Moreover, the role of gender has been scarcely investigated. The present study sought to fill the gap in the data by examining the associations, if any, between moderate-to-vigorous physica...

journal_title：PeerJ

authors： Liu M,Zhang J,Kamper-DeMarco KE,Hu E,Yao S

更新日期：2020-03-25 00:00:00

abstract：:Grazing and litter removal can alter understory structure and composition after afforestation, posing a serious threat to sustainable forest development. Enclosure is considered to be an effective measure to restore degraded forest restoration. However, little is known about the dynamics of soil nutrients and microbia...

journal_title：PeerJ

authors： Deng J,Zhou Y,Zhu W,Yin Y

更新日期：2020-03-25 00:00:00

abstract：:As a vector of Xylella fastidiosa (Wells, 1987) in Europe, the meadow spittlebug Philaenus spumarius (Linnaeus, 1758) (Hemiptera, Aphrophoridae) is a species of major concern. Therefore, tools and agents to control this ubiquitous insect that develops and feeds on hundreds of plant species are wanted. We conducted a f...

journal_title：PeerJ

authors： Mesmin X,Chartois M,Genson G,Rossi JP,Cruaud A,Rasplus JY

更新日期：2020-03-24 00:00:00

abstract：:Pueraria lobata (willd.) Ohwi is a consumable selenium-enriched plant used for medicinal purposes. The molecular response to selenium (Se) stimuli in P. lobata is currently unknown. We used RNA-Seq to identify potential genes involved in selenite metabolism and analyzed their expression profiles. We obtained a total o...

journal_title：PeerJ

authors： Guo K,Yao Y,Yang M,Li Y,Wu B,Lin X

更新日期：2020-03-24 00:00:00

abstract：Background:Alzheimer's disease (AD) is a prevalent progressive neurodegenerative human disease whose cause remains unclear. Numerous initially highly hopeful anti-AD drugs based on the amyloid-β (Aβ) hypothesis of AD have failed recent late-phase tests. Natural aging (AG) is a high-risk factor for AD. Here, we aim to g...

journal_title：PeerJ

authors： Peng YS,Tang CW,Peng YY,Chang H,Chen CL,Guo SL,Wu LC,Huang MC,Lee HC

更新日期：2020-03-20 00:00:00

abstract：:Sex reversal is a complex biological phenomenon exhibited by Cynoglossus semilaevis. Some genetic females may irreversibly convert to pseudomales, thus increasing aquaculture costs because males grow much more slowly than females. In this study, an integrative analysis of transcriptome and proteome was performed to co...

journal_title：PeerJ

authors： Ye Z,Wang W,Zhang Y,Wang L,Cui Y,Li H

更新日期：2020-03-19 00:00:00

abstract：:Trypophobia is a strong emotion of disgust evoked by clusters of holes or round objects (e.g., lotus seed pod). It has become increasingly popular and been studied since 2010s, mainly in the West and Japan. Considering this, trypophobia might be a modern emotion, and hence urbanization possibly plays key roles in tryp...

journal_title：PeerJ

authors： Zhu S,Sasaki K,Jiang Y,Qian K,Yamada Y

更新日期：2020-03-18 00:00:00

abstract：Background:WRKY proteins play a vital role in the plants response to different stresses, growth and development. Studies of WRKY proteins have been mainly focused on model plant Arabidopsis and a few other vegetable plants. However, the systematical study of eggplant WRKY transcription factor superfamily is scarce. Me...

journal_title：PeerJ

authors： Yang Y,Liu J,Zhou X,Liu S,Zhuang Y

更新日期：2020-03-17 00:00:00

abstract：Background:Leucojum aestivum L. is an important medicinal plant which produces Amaryllidaceae alkaloids, especially galanthamine and lycorine. Research is currently exploring the possibility of producing these alkaloids using biotechnological methods, including in vitro cultures. The biosynthesis of alkaloids may be af...

journal_title：PeerJ

authors： Ptak A,Morańska E,Skrzypek E,Warchoł M,Spina R,Laurain-Mattar D,Simlat M

更新日期：2020-03-16 00:00:00

abstract：:Trihelix transcription factors play multiple roles in plant growth, development and various stress responses. In this study, we identified 71 trihelix family genes in the soybean genome. These trihelix genes were located at 19 out of 20 soybean chromosomes unevenly and were classified into six distinct subfamilies: GT...

journal_title：PeerJ

authors： Liu W,Zhang Y,Li W,Lin Y,Wang C,Xu R,Zhang L

更新日期：2020-03-13 00:00:00

abstract：:Histopathological images contain rich phenotypic descriptions of the molecular processes underlying disease progression. Convolutional neural networks, state-of-the-art image analysis techniques in computer vision, automatically learn representative features from such images which can be useful for disease diagnosis, ...

journal_title：PeerJ

authors： Lu L,Daigle BJ Jr

更新日期：2020-03-12 00:00:00

abstract：Background:Over the last two decades, there has been a constant increase in prescription rates of antidepressants. In parallel, neuroactive pharmaceuticals are making their way into aquatic environments at increasing concentrations. Among the antidepressants detected in the environment citalopram, a selective serotonin...

journal_title：PeerJ

authors： Ziegler M,Knoll S,Köhler HR,Tisler S,Huhn C,Zwiener C,Triebskorn R

更新日期：2020-03-12 00:00:00

abstract：:Seymouria is the best known of the seymouriamorphs, a group of Permo-Carboniferous reptiliomorphs with both terrestrial and aquatic taxa. The majority of research on Seymouria has focused on cranial anatomy, with few detailed descriptions or illustrations of the postcrania. We utilized neutron computed tomography (nCT...

journal_title：PeerJ

authors： Bazzana KD,Gee BM,Bevitt JJ,Reisz RR

更新日期：2020-03-10 00:00:00

abstract：Background:Caseinolytic protease P (ClpP), which is located on the inner mitochondrial membrane, degrades mitochondrial proteins damaged by oxidative stress. The role of ClpP varies among tumor types. However, the expression pattern and biological functions of ClpP in breast cancer (BC) have not yet been investigated. ...

journal_title：PeerJ

authors： Luo J,Zeng B,Tao C,Lu M,Ren G

更新日期：2020-03-10 00:00:00

abstract：Background:This study was performed to determine the characteristics of community cats that were admitted to trap-neuter-return(TNR) programs and the feasibility of the high-quality, high-volume spay/neuter (HQHVSN) model in Seoul, Korea. Methods:TNR programs were performed eight times from 2017 to 2018, and a total o...

journal_title：PeerJ

authors： Cho Y,Kim K,Kim MS,Lee I

更新日期：2020-03-05 00:00:00

abstract：:Temperature-dependent sex determination, or TSD, is a widespread phenomenon in reptiles. The shape of the relationship between constant incubation temperature and sex ratio defines the TSD pattern. The TSD pattern is considered a life-history parameter important for conservation because the wider the range of temperat...

journal_title：PeerJ

authors： Abreu-Grobois FA,Morales-Mérida BA,Hart CE,Guillon JM,Godfrey MH,Navarro E,Girondot M

更新日期：2020-03-04 00:00:00

abstract：:Permineralized peat from the central Transantarctic Mountains of Antarctica has provided a wealth of information on plant and fungal diversity in Middle Triassic high-latitude forest paleoecosystems; however, there are no reports as yet of algae or cyanobacteria. The first record of a fossil filamentous cyanobacterium...

journal_title：PeerJ

authors： Harper CJ,Taylor EL,Krings M

更新日期：2020-03-02 00:00:00

abstract：Background:Fatigue influences athletic performance and can also increase the risk of injury in sports, and most of the methods to evaluate it require an additional voluntary effort. Tensiomyography (TMG), which uses electrical stimulation and a displacement sensor to evaluate muscle contraction properties of one or mor...

journal_title：PeerJ

authors： Martín-San Agustín R,Medina-Mirapeix F,Casaña-Granell J,García-Vidal JA,Lillo-Navarro C,Benítez-Martínez JC

更新日期：2020-02-28 00:00:00

abstract：:In this study, four experimental assays were conducted to evaluate the use of a new silver nanoparticle formulation named Argovit-4, which was prepared with slight modifications to enhance its biological activity against white spot syndrome virus (WSSV) in shrimp culture. The goals of these assays were to (1) determin...

journal_title：PeerJ

authors： Romo-Quiñonez CR,Álvarez-Sánchez AR,Álvarez-Ruiz P,Chávez-Sánchez MC,Bogdanchikova N,Pestryakov A,Mejia-Ruiz CH

更新日期：2020-02-27 00:00:00

abstract：:The massive influx of pelagic Sargassum spp. (sargasso) into the Mexican Caribbean Sea has caused major deterioration of the coastal environment and has affected the tourism industry as well as livelihoods since 2015. Species of Sargassum have high capacity to absorb metals; thus, leachates of sargasso may contribute ...

journal_title：PeerJ

authors： Rodríguez-Martínez RE,Roy PD,Torrescano-Valle N,Cabanillas-Terán N,Carrillo-Domínguez S,Collado-Vides L,García-Sánchez M,van Tussenbroek BI

更新日期：2020-02-26 00:00:00

abstract：:Wildlife demography is typically studied at a single point in time within a year when species, often during the reproductive season, are more active and therefore easier to find. However, this provides only a low-resolution glimpse into demographic temporal patterns over time and may hamper a more complete understandi...

journal_title：PeerJ

authors： Guimarães M,Correa DT,Gaiarsa MP,Kéry M

更新日期：2020-02-25 00:00:00

abstract：Background:Many fish taxa produce sound in voluntary and in disturbance contexts but information on the full acoustic repertoire is lacking for most species. Yet, this knowledge is critical to enable monitoring fish populations in nature through acoustic monitoring. Methods:In this study we characterized the sounds em...

journal_title：PeerJ

authors： Pereira BP,Vieira M,Pousão-Ferreira P,Candeias-Mendes A,Barata M,Fonseca PJ,Amorim MCP

更新日期：2020-02-24 00:00:00

abstract：:The mammalian pelvis is thought to exhibit adaptations to the functional demands of locomotor behaviors. Previous work in primates has identified form-function relationships between pelvic shape and locomotor behavior; few studies have documented such relationships in carnivorans, instead focusing on long bones. Most ...

journal_title：PeerJ

authors： Lewton KL,Brankovic R,Byrd WA,Cruz D,Morales J,Shin S

更新日期：2020-02-20 00:00:00